1. What is the Cytiva Linear Flow Rate Calculator?

Definition: This calculator determines the linear flow rate (velocity) for Cytiva bioprocessing systems based on volumetric flow rate and cross-sectional area.

Purpose: It helps bioprocessing engineers optimize flow conditions for chromatography columns and other bioprocessing equipment.

2. How Does the Calculator Work?

The calculator uses the formula:

Where:

• \( V \) — Linear flow rate (feet per second)
• \( Q \) — Volumetric flow rate (gallons per minute)
• \( A \) — Cross-sectional area (square feet)
• 448.83 — Conversion factor (GPM to ft³/s)

Explanation: The formula converts volumetric flow rate to linear velocity by accounting for the flow area and unit conversions.

3. Importance of Linear Flow Rate Calculation

Details: Proper flow rate calculation ensures optimal residence time, efficient mass transfer, and consistent product quality in bioprocessing applications.

4. Using the Calculator

Tips: Enter the volumetric flow rate in GPM and the cross-sectional area in square feet. Both values must be > 0.

5. Frequently Asked Questions (FAQ)

Q1: Why is 448.83 used in the formula?
A: This converts gallons per minute to cubic feet per second (1 GPM = 0.002228 ft³/s, inverse is ~448.83).

Q2: What's a typical linear flow rate for chromatography?
A: Typically ranges from 0.5 to 5 cm/min (0.0027 to 0.027 ft/s), depending on the resin and process requirements.

Q3: How do I find the cross-sectional area?
A: For cylindrical columns: \( A = \pi \times r^2 \), where r is the radius in feet.

Q4: Can I use this for non-Cytiva systems?
A: Yes, the calculation is universal for any system using GPM and ft² units.

Q5: What if I need cm/min instead of ft/s?
A: Multiply the result by 1828.8 to convert ft/s to cm/min.